Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

David Castel; Thomas Kergrohen; Arnault Tauziède-Espariat; Alan Mackay; Samia Ghermaoui; Emmanuèle Lechapt; Stefan M Pfister; Christof M Kramm; Nathalie Boddaert; Thomas Blauwblomme; Stéphanie Puget; Kévin Beccaria; Chris Jones; David T W Jones; Pascale Varlet; Jacques Grill; Marie-Anne Debily

doi:10.1007/s00401-020-02142-w

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

Acta Neuropathol. 2020 Jun;139(6):1109-1113. doi: 10.1007/s00401-020-02142-w. Epub 2020 Mar 19.

Authors

David Castel^{1

2}, Thomas Kergrohen^{3

4}, Arnault Tauziède-Espariat^{5

6}, Alan Mackay⁷, Samia Ghermaoui³, Emmanuèle Lechapt^{5

6}, Stefan M Pfister^{8

9

10}, Christof M Kramm¹¹, Nathalie Boddaert¹², Thomas Blauwblomme¹³, Stéphanie Puget¹³, Kévin Beccaria^{3

13}, Chris Jones⁷, David T W Jones^{8

14}, Pascale Varlet^{5

6}, Jacques Grill^{3

4}, Marie-Anne Debily^{15

16}

Affiliations

¹ Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France. david.castel@gustaveroussy.fr.
² Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France. david.castel@gustaveroussy.fr.
³ Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France.
⁴ Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁵ Department of Neuropathology, GHU Paris Psychiatrie Neurosciences, Sainte-Anne Hospital, Paris, France.
⁶ Université de Paris, Paris, France.
⁷ Divisions of Molecular Pathology, The Institute of Cancer Research, London, UK.
⁸ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
⁹ Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
¹⁰ Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
¹¹ Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany.
¹² Department of Pediatric Radiology, IMAGINE Institute, INSERM UMR 1163, INSERM U1000, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France.
¹³ Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, APHP, Université de Paris, Paris, France.
¹⁴ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France. marie-anne.debily@gustaveroussy.fr.
¹⁶ Département de Biologie, Univ. Evry, Université Paris-Saclay, 23 boulevard de France, Evry, 91000, France. marie-anne.debily@gustaveroussy.fr.

PMID: 32193787
DOI: 10.1007/s00401-020-02142-w

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms / genetics*
Brain Neoplasms / pathology
Glioma / genetics*
Glutamates / metabolism
Histones / genetics*
Humans
Mutation / genetics*
Oncogene Proteins / genetics*
Transcription Factors / metabolism

Substances

EZHIP protein, human
Glutamates
Histones
Oncogene Proteins
Transcription Factors
peroxisome-proliferator-activated receptor-gamma coactivator-1
dipinacoline glutamate