Localization of the gene encoding human factor V to chromosome 1q21-25

Genomics. 1988 May;2(4):324-8. doi: 10.1016/0888-7543(88)90021-3.

Abstract

The gene encoding human coagulation Factor V (FV), one of the cofactors in the blood clotting process, has been mapped to chromosome 1 by both Southern hybridization to DNA from human-hamster somatic cell hybrids and in situ hybridization. The whole plasmid pUC3A containing a 1.5-kb cDNA sequence for FV was 32P-labeled for Southern analysis and 3H-labeled for in situ hybridization to metaphase chromosomes. The results localized the FV gene to the region of 1q21-25.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Cloning, Molecular
  • Cricetinae
  • DNA / genetics
  • Factor V / genetics*
  • Genes*
  • Humans
  • Hybrid Cells / cytology
  • Nucleic Acid Hybridization

Substances

  • Factor V
  • DNA