Clinicopathological analysis of oral Burkitt's lymphoma in pediatric patients: A systematic review

Carla Isabelly Rodrigues-Fernandes; Maria Eduarda Pérez-de-Oliveira; Lady Paola Aristizabal Arboleda; Felipe Paiva Fonseca; Márcio Ajudarte Lopes; Pablo Agustin Vargas; Alan Roger Santos-Silva

doi:10.1016/j.ijporl.2020.110033

Clinicopathological analysis of oral Burkitt's lymphoma in pediatric patients: A systematic review

Int J Pediatr Otorhinolaryngol. 2020 Jul:134:110033. doi: 10.1016/j.ijporl.2020.110033. Epub 2020 Apr 5.

Authors

Carla Isabelly Rodrigues-Fernandes¹, Maria Eduarda Pérez-de-Oliveira¹, Lady Paola Aristizabal Arboleda¹, Felipe Paiva Fonseca², Márcio Ajudarte Lopes¹, Pablo Agustin Vargas³, Alan Roger Santos-Silva⁴

Affiliations

¹ Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil.
² Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Brazil; Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa.
³ Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil; Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa.
⁴ Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil. Electronic address: alan@unicamp.br.

PMID: 32302884
DOI: 10.1016/j.ijporl.2020.110033

Abstract

The aim of this study was to integrate the available data regarding pediatric Burkitt's lymphoma (BL) of the oral cavity. A systematic review was conducted following PRISMA guidelines, through a specific search strategy. Twenty-nine publications were included in this study, resulting in a total of 144 cases. Oral BL was predominantly found in males (75.7%). The mandible was the most involved site (37.5%), and all cases clinically exhibited a swelling. Presence of EBV was observed in 33.3% of the cases, and 4 cases reported HIV-positive patients (33.3%). Chemotherapy was the leading treatment choice for oral BL (94.9%), and the overall 5-year survival was 54.3%. Regarding the quality assessment of the studies, most (19 studies; 65.5%) were classified as an overall moderate risk of bias. In conclusion, the clinicopathological characteristics of oral BL in the pediatric population comprise the sporadic and intermediate subtypes. Despite its aggressiveness, this malignancy presents a moderate overall survival.

Keywords: Burkitt's lymphoma; Mandible; Maxilla; Oral cavity.; Pediatric lymphoma.

Publication types

Systematic Review

MeSH terms

Adolescent
Burkitt Lymphoma / diagnosis*
Burkitt Lymphoma / mortality
Burkitt Lymphoma / pathology*
Burkitt Lymphoma / therapy
Child
Child, Preschool
Combined Modality Therapy
Female
Humans
Infant
Infant, Newborn
Male
Mouth Neoplasms / diagnosis*
Mouth Neoplasms / mortality
Mouth Neoplasms / pathology*
Mouth Neoplasms / therapy
Prognosis
Survival Analysis
Young Adult