Does the GABA Shunt Regulate Cytosolic GABA?

Alan W Bown; Barry J Shelp

doi:10.1016/j.tplants.2020.03.001

Does the GABA Shunt Regulate Cytosolic GABA?

Trends Plant Sci. 2020 May;25(5):422-424. doi: 10.1016/j.tplants.2020.03.001. Epub 2020 Mar 16.

Authors

Alan W Bown¹, Barry J Shelp²

Affiliations

¹ Department of Biological Sciences, Brock University, St. Catharines, ON, Canada L2S 3A1.
² Department of Plant Agriculture, University of Guelph, Guelph, ON, Canada N1G 2W1. Electronic address: bshelp@uoguelph.ca.

PMID: 32304653
DOI: 10.1016/j.tplants.2020.03.001

Abstract

The GABA shunt has long been known as a metabolic pathway that produces GABA in, and removes GABA from, the cytosol. There is no consensus regarding its function. The hypothesis presented here is that the GABA shunt regulates cytosolic GABA levels and GABA signaling.

Keywords: GABA; regulation; shunt; signal.

MeSH terms

Cytosol / metabolism
Metabolic Networks and Pathways*
Signal Transduction*
gamma-Aminobutyric Acid / metabolism

Substances

gamma-Aminobutyric Acid