Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. The relevant data was extracted and a meta-analysis was performed using StatsDirect statistical software V.2.8.0 to calculate the combined odds ratio. Results: Seven studies were included, consisting of 1594 cases. The meta-analysis result showed that the most common clinical symptoms of the novel coronavirus pneumonia were fever (91.6%) and cough (64.5%), followed by dyspnea (32.8%) and sputum (28.1%). Headache (10.5%), sore throat (11.2%), hemoptysis (3.2%), diarrhea (6.6%) and the other symptoms were relatively rare. Aspartate aminotransferase (29%), alanine transaminase (22.7%), and total bilirubin (11.7%) levels were elevated, except for serum albumin levels (80.4%). The common therapeutic agents used were antibiotics (87.7%), antiviral drugs (75.5%), and glucocorticoids (26.6%), while antifungal agents (7.7%) were used in few. Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. The rate of mortality in hospital was 7.7%, respectively. Heterogeneity between studies was significant; however, subgroup and sensitivity analysis had failed to identify clear sources of heterogeneity. Conclusion: Fever, cough and liver dysfunction are the main clinical manifestations of this disease and the mortality rate is low.
目的： 自2019年12月首次报道新型冠状病毒肺炎以来，该传染病已迅速发生于全国各地及海外多个国家。通过荟萃分析方法探讨新型冠状病毒肺炎的临床特征及预后。 方法： 检索PubMed（Medline）和EMBASE数据库发表的关于新型冠状病毒肺炎的文献。提取相关数据并用StatsDirect 2.8.0统计软件进行率的荟萃分析，计算合并的率。 结果： 共纳入7项研究，包括1 594例患者。荟萃分析结果显示：新型冠状病毒肺炎最常见的临床症状是发热（91.6%）和咳嗽（64.5%），其次是呼吸困难（32.8%）和咳痰（28.1%），而头痛（10.5%）、咽痛（11.2%）、咯血（3.2%）及腹泻（6.6%）等症状相对少见。肝功能异常包括天冬氨酸转氨酶水平升高（发病率为29.0%）、丙氨酸转氨酶水平升高（22.7%）、总胆红素水平升高（11.7%）、血清白蛋白水平降低（80.4%）。常用的治疗药物包括抗生素（87.7%）、抗病毒药物（75.5%）以及糖皮质激素（26.6%），少数患者也采用了抗真菌药物（7.7%）。严重者也应用了机械通气（13.4%）、体外膜肺氧合（1.9%）、连续性肾脏替代治疗（3.8%）。院内病死率为7.7%。研究间的异质性显著，但亚组分析及敏感性分析未能鉴定出明确异质性来源。 结论： 基于现已发表文献数据，系统分析新型冠状病毒肺炎的临床特征及治疗结局，该病以发热及咳嗽为主要临床表现，肝功能异常较常见，致死率较低。.
Keywords: 2019 novel coronavirus pneumonia; Antiviral; Clinical manifestation; Mortality; Treatment.