Vaccines represent some of the most stunning successes in improving health around the world. However, vaccine skepticism, whether voiced privately in the offices of healthcare providers or amplified through social and traditional media, threatens to erode these hard-won gains. Vaccine refusal is not, unfortunately, a new problem, but providers need new tools to address it given the ease with which misinformation spreads in the digital age. Presented here are several practical strategies that allergists can use to turn frustration around vaccine hesitancy into empowered advocacy and protect the patients you work so hard to serve.