Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons

Matthew M McGregor; Alexandra B Nelson

doi:10.1016/j.neuron.2020.04.005

Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons

Neuron. 2020 Apr 22;106(2):201-203. doi: 10.1016/j.neuron.2020.04.005.

Authors

Matthew M McGregor¹, Alexandra B Nelson²

Affiliations

¹ Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA.
² Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA; Department of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: alexandra.nelson@ucsf.edu.

PMID: 32325053
DOI: 10.1016/j.neuron.2020.04.005

Abstract

In this issue of Neuron, Lahiri and Bevan (2020) investigate the effects of dopamine release on striatal projection neurons. Using perforated patch recordings and optogenetics, they show that dopamine release persistently enhances the intrinsic excitability of direct pathway striatal neurons.

Publication types

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MeSH terms

Corpus Striatum*
Dopamine*
Neurons
Receptors, Dopamine D1
Receptors, Dopamine D2

Substances

Receptors, Dopamine D1
Receptors, Dopamine D2
Dopamine