Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management

Stroke Vasc Neurol. 2020 Jun;5(2):177-179. doi: 10.1136/svn-2020-000398. Epub 2020 May 4.

Abstract

Coronavirus disease-2019 (COVID-19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1-2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. The key is to prevent a patient from progressing to this severe infection from mild infection. We are sharing our experience on prevention and management of COVID-19.

Keywords: brain; infection; intervention; stroke.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Betacoronavirus / pathogenicity*
  • COVID-19
  • COVID-19 Testing
  • Central Nervous System / physiopathology
  • Central Nervous System / virology*
  • Central Nervous System Infections / diagnosis
  • Central Nervous System Infections / physiopathology
  • Central Nervous System Infections / therapy*
  • Central Nervous System Infections / virology
  • Clinical Laboratory Techniques
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / physiopathology
  • Coronavirus Infections / therapy*
  • Coronavirus Infections / virology
  • Disease Progression
  • Early Diagnosis
  • Host-Pathogen Interactions
  • Humans
  • Pandemics
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / physiopathology
  • Pneumonia, Viral / therapy*
  • Pneumonia, Viral / virology
  • Predictive Value of Tests
  • Prognosis
  • SARS-CoV-2
  • Time Factors