Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies

Chao-Ran Li; Lang Chen; Long-Fei Wang; Bin Yan; You-Ling Liang; Jing Luo

doi:10.18240/ijo.2020.04.19

Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies

Int J Ophthalmol. 2020 Apr 18;13(4):650-659. doi: 10.18240/ijo.2020.04.19. eCollection 2020.

Authors

Chao-Ran Li¹, Lang Chen², Long-Fei Wang³, Bin Yan¹, You-Ling Liang¹, Jing Luo¹

Affiliations

¹ Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
² General Surgery Department, the Third Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
³ Cardiovascular Department, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Abstract

Aim: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other.

Methods: We performed a comprehensive search of PubMed and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis (PsA)]. We used a random-effects model to calculate the pooled relative risks (RRs) adjusted for confounders, along with the 95% confidence intervals (CIs).

Results: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis (RR=1.49; 95%CI: 1.08-2.07), and PsA (RR=3.16; 95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis (RR=1.62; 95%CI: 1.44-1.83), and PsA (RR=4.44; 95%CI: 3.52-5.60).

Conclusion: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease (psoriasis and PsA), warranting increased awareness among clinicians involved in the management of these two conditions. Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis.

Keywords: Meta-analysis; psoriasis; psoriatic arthritis; risk; uveitis.

International Journal of Ophthalmology Press.