Abstract
Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARS-CoV-2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit the spread of SARS-CoV-2 and morbidity and mortality due to the COVID-19 pandemic.
Keywords:
3Clpro; COVID-19; Camostat; Coronavirus SARS-CoV-2; RNA polymerase; Remdesivir; S protein; α-Ketoamides.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
MeSH terms
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Angiotensin-Converting Enzyme 2
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Antiviral Agents / therapeutic use*
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Betacoronavirus / drug effects*
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COVID-19
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COVID-19 Drug Treatment
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Coronavirus 3C Proteases
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Coronavirus Infections / drug therapy*
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Coronavirus Infections / virology
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Coronavirus RNA-Dependent RNA Polymerase
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Cysteine Endopeptidases
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Drug Repositioning*
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Humans
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Pandemics
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Peptidyl-Dipeptidase A / chemistry
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Pneumonia, Viral / drug therapy*
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Pneumonia, Viral / virology
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RNA-Dependent RNA Polymerase / antagonists & inhibitors
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SARS-CoV-2
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Spike Glycoprotein, Coronavirus / antagonists & inhibitors
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Viral Nonstructural Proteins / antagonists & inhibitors
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Virus Internalization*
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Virus Replication*
Substances
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Antiviral Agents
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Spike Glycoprotein, Coronavirus
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Viral Nonstructural Proteins
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spike protein, SARS-CoV-2
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Coronavirus RNA-Dependent RNA Polymerase
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NSP12 protein, SARS-CoV-2
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RNA-Dependent RNA Polymerase
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2
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Cysteine Endopeptidases
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Coronavirus 3C Proteases