Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

JAMA. 2020 Jun 16;323(23):2427-2429. doi: 10.1001/jama.2020.8707.

Abstract

This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Angiotensin-Converting Enzyme 2
  • Asthma / epidemiology
  • Betacoronavirus / physiology
  • COVID-19
  • Child
  • Child, Preschool
  • Coronavirus Infections / virology
  • Female
  • Gene Expression*
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Nasal Mucosa* / virology
  • Pandemics
  • Peptidyl-Dipeptidase A / genetics*
  • Pneumonia, Viral / virology
  • Retrospective Studies
  • SARS-CoV-2
  • Sex Factors
  • Virus Internalization
  • Young Adult

Substances

  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2