The Association of BAP1 Loss-of-Function With the Defect in Homologous Recombination Repair and Sensitivity to PARP-Targeted Therapy

J Thorac Oncol. 2020 Jun;15(6):e88-e90. doi: 10.1016/j.jtho.2020.02.028.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA
  • DNA Repair
  • Guanine / analogs & derivatives
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Mesothelioma*
  • Methyltransferases
  • Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use
  • Recombinational DNA Repair
  • Temozolomide
  • Tumor Suppressor Proteins
  • Ubiquitin Thiolesterase

Substances

  • BAP1 protein, human
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Tumor Suppressor Proteins
  • Guanine
  • DNA
  • O-(6)-methylguanine
  • Methyltransferases
  • Ubiquitin Thiolesterase
  • Temozolomide