Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Shen-Ying Zhang; Qian Zhang; Jean-Laurent Casanova; Helen C Su; COVID Team

doi:10.1038/s41577-020-0373-7

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Nat Rev Immunol. 2020 Aug;20(8):455-456. doi: 10.1038/s41577-020-0373-7.

Authors

Shen-Ying Zhang^{1

2

3}, Qian Zhang^{4

5

6}, Jean-Laurent Casanova^{7

8

9

10

11}, Helen C Su¹²; COVID Team

Collaborators

COVID Team:
Laurent Abel, Paul Bastard, Aurélie Cobat, Emmanuelle Jouanguy, Luigi Notarangelo

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. shzh289@rockefeller.edu.
² Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. shzh289@rockefeller.edu.
³ University of Paris, Imagine Institute, Paris, France. shzh289@rockefeller.edu.
⁴ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. qzhang02@rockefeller.edu.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. qzhang02@rockefeller.edu.
⁶ University of Paris, Imagine Institute, Paris, France. qzhang02@rockefeller.edu.
⁷ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu.
⁸ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France. casanova@rockefeller.edu.
⁹ University of Paris, Imagine Institute, Paris, France. casanova@rockefeller.edu.
¹⁰ Howard Hughes Medical Institute, New York, NY, USA. casanova@rockefeller.edu.
¹¹ Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.
¹² Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Betacoronavirus / immunology*
COVID-19
Coronavirus Infections / immunology*
Genetic Diseases, Inborn / immunology*
Humans
Immunity / immunology*
Pandemics
Pneumonia, Viral / immunology*
SARS-CoV-2

Abstract

Publication types

MeSH terms

Grants and funding