18F-Fluciclovine PET/MRI in a Patient With Squamous Cell Carcinoma of the Uterine Cervix Correlated With 18F-FDG PET/CT

Clin Nucl Med. 2020 Oct;45(10):802-804. doi: 10.1097/RLU.0000000000003139.

Abstract

A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a potential advantage over FDG of minimal urinary activity from renal excretion; however, in this patient, the metabolic activity was inferior to that of FDG PET.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carboxylic Acids*
  • Carcinoma, Squamous Cell / diagnostic imaging*
  • Cyclobutanes*
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Magnetic Resonance Imaging
  • Positron Emission Tomography Computed Tomography*
  • Uterine Cervical Neoplasms / diagnostic imaging*

Substances

  • Carboxylic Acids
  • Cyclobutanes
  • Fluorodeoxyglucose F18
  • fluciclovine F-18