Abstract
Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This suggests that COVID-19 may modulate the red cell membrane and present novel antigenic epitopes.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Aged, 80 and over
-
Anemia / complications
-
Anemia / immunology
-
Anemia / therapy
-
Autoantibodies / analysis
-
Autoantibodies / immunology
-
Betacoronavirus / immunology
-
Betacoronavirus / isolation & purification
-
Blood Transfusion
-
COVID-19
-
Coombs Test
-
Coronavirus Infections / complications
-
Coronavirus Infections / immunology
-
Coronavirus Infections / therapy*
-
Erythrocytes / immunology*
-
Female
-
Humans
-
Immunoglobulin G / analysis
-
Immunoglobulin G / immunology*
-
Male
-
Middle Aged
-
Pandemics
-
Pneumonia, Viral / complications
-
Pneumonia, Viral / immunology
-
Pneumonia, Viral / therapy*
-
SARS-CoV-2
Substances
-
Autoantibodies
-
Immunoglobulin G