Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Xinyi Xia; Kening Li; Lingxiang Wu; Zhihua Wang; Mengyan Zhu; Bin Huang; Jie Li; Ziyu Wang; Wei Wu; Min Wu; Wanlin Li; Lu Li; Yun Cai; Bakwatanisa Bosco; Aifang Zhong; Xiong Liu; Tangfeng Lv; Zhenhua Gan; Guang Chen; Yunhu Pan; Caidong Liu; Kai Zhang; Xiaoli Xu; Changjun Wang; Qianghu Wang

doi:10.1182/blood.2020007079

Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Blood. 2020 Aug 6;136(6):755-759. doi: 10.1182/blood.2020007079.

Authors

Xinyi Xia^{1

2

3}, Kening Li^{4

5}, Lingxiang Wu^{4

5}, Zhihua Wang^{2

3

6}, Mengyan Zhu^{4

5}, Bin Huang^{4

5}, Jie Li^{4

5}, Ziyu Wang^{4

5}, Wei Wu^{4

5}, Min Wu^{4

5}, Wanlin Li^{4

5}, Lu Li^{4

5}, Yun Cai^{4

5}, Bakwatanisa Bosco^{4

5}, Aifang Zhong^{2

7}, Xiong Liu^{3

8}, Tangfeng Lv^{3

9

10}, Zhenhua Gan^{3

9}, Guang Chen^{10

11}, Yunhu Pan^{10

12}, Caidong Liu¹³, Kai Zhang¹³, Xiaoli Xu^{3

9

10}, Changjun Wang^{3

8}, Qianghu Wang^{4

5

14}

Affiliations

¹ COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
² Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, Wuhan, China.
³ Joint Expert Group for COVID-19, Wuhan Huoshenshan Hospital, Wuhan, China.
⁴ Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
⁵ Department of Bioinformatics, Nanjing Medical University, Nanjing, China.
⁶ Department of Laboratory Medicine & Blood Transfusion, the 907th Hospital, Nanping, China.
⁷ Medical Technical Support Division, the 904th Hospital, Changzhou, China.
⁸ Center for Disease Control and Prevention of PLA, Beijing, China.
⁹ Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
¹⁰ Department of Infectious Disease, Wuhan Huoshenshan Hospital, Wuhan, China.
¹¹ Department of Respiratory Medicine, the 907th Hospital, Nanping, China.
¹² Intensive Care Unit, the 907th Hospital, Nanping, China.
¹³ General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; and.
¹⁴ Biomedical Big Data Center, Nanjing Medical University, Nanjing, China.

Abstract

Two case series examining the impact of convalescent plasma on patients with COVID-19 suggest some clinical benefit from early administration and modest impact on parameters of inflammation. Further assessment of the impact of this intervention awaits controlled clinical trials.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Betacoronavirus / isolation & purification
Betacoronavirus / physiology
Blood Component Transfusion / methods
COVID-19
COVID-19 Serotherapy
China / epidemiology
Coronavirus Infections / diagnosis
Coronavirus Infections / epidemiology
Coronavirus Infections / therapy*
Female
Humans
Immunization, Passive / methods
Male
Middle Aged
Pandemics
Pneumonia, Viral / diagnosis
Pneumonia, Viral / epidemiology
Pneumonia, Viral / therapy*
SARS-CoV-2
Treatment Outcome
Viral Load