Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen; Xiaolu Long; Qian Xu; Jiaqi Tan; Gaoxiang Wang; Yang Cao; Jia Wei; Hui Luo; Hui Zhu; Liang Huang; Fankai Meng; Lifang Huang; Na Wang; Xiaoxi Zhou; Lei Zhao; Xing Chen; Zekai Mao; Caixia Chen; Zhen Li; Ziyong Sun; Jianping Zhao; Daowen Wang; Gang Huang; Wei Wang; Jianfeng Zhou

doi:10.1038/s41423-020-0492-x

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Cell Mol Immunol. 2020 Sep;17(9):992-994. doi: 10.1038/s41423-020-0492-x. Epub 2020 Jul 3.

Authors

Liting Chen^#¹, Xiaolu Long^#¹, Qian Xu^#¹, Jiaqi Tan^#², Gaoxiang Wang¹, Yang Cao, Jia Wei¹, Hui Luo¹, Hui Zhu³, Liang Huang¹, Fankai Meng¹, Lifang Huang¹, Na Wang¹, Xiaoxi Zhou¹, Lei Zhao¹, Xing Chen¹, Zekai Mao¹, Caixia Chen¹, Zhen Li³, Ziyong Sun⁴, Jianping Zhao⁵, Daowen Wang⁶, Gang Huang⁷, Wei Wang⁸, Jianfeng Zhou⁹

Affiliations

¹ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China.
² Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China.
³ Department of Medical Imageology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China.
⁴ Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
⁵ Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Key Cite of National Clinical Research Center for Respiratory Disease, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan, 430030, China.
⁶ Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
⁷ Divisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Room S7.224, Cincinnati, OH, USA. Gang.Huang@cchmc.org.
⁸ Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China. wwang@vip.126.com.
⁹ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China. jfzhou@tjh.tjmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury / complications
Acute Kidney Injury / diagnosis*
Acute Kidney Injury / mortality
Acute Kidney Injury / virology
Betacoronavirus / pathogenicity*
Biomarkers / blood
COVID-19
Calgranulin A / blood*
Calgranulin B / blood*
Case-Control Studies
China
Coronavirus Infections / complications
Coronavirus Infections / diagnosis*
Coronavirus Infections / mortality
Coronavirus Infections / virology
Cytokine Release Syndrome / complications
Cytokine Release Syndrome / diagnosis*
Cytokine Release Syndrome / mortality
Cytokine Release Syndrome / virology
HMGB1 Protein / blood
HMGB1 Protein / genetics
Humans
Intensive Care Units
Lymphocytes / pathology
Lymphocytes / virology
Neutrophils / pathology
Neutrophils / virology
Pandemics
Patient Admission
Pneumonia, Viral / complications
Pneumonia, Viral / diagnosis*
Pneumonia, Viral / mortality
Pneumonia, Viral / virology
Prognosis
ROC Curve
Retrospective Studies
SARS-CoV-2
Severe Acute Respiratory Syndrome / complications
Severe Acute Respiratory Syndrome / diagnosis*
Severe Acute Respiratory Syndrome / mortality
Severe Acute Respiratory Syndrome / virology
Shock, Septic / complications
Shock, Septic / diagnosis*
Shock, Septic / mortality
Shock, Septic / virology
Survival Analysis

Substances

Biomarkers
Calgranulin A
Calgranulin B
HMGB1 Protein
HMGB1 protein, human
S100A8 protein, human
S100A9 protein, human