Effects of Liraglutide on Cardiovascular Outcomes in Type 2 Diabetes Patients With and Without Baseline Metformin Use: Post Hoc Analyses of the LEADER Trial

Diabetes Care. 2020 Sep;43(9):e108-e110. doi: 10.2337/dc20-0437. Epub 2020 Jul 9.

Authors

Matthew J Crowley^{1

2}, Darren K McGuire³, Anastasia-Stefania Alexopoulos^{4

2}, Thomas Jon Jensen⁵, Søren Rasmussen⁵, Hans A Saevereid⁵, Subodh Verma⁶, John B Buse⁷

Affiliations

¹ Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, NC matthew.crowley@duke.edu.
² Durham Veterans Affairs Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham, NC.
³ Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
⁴ Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, NC.
⁵ Novo Nordisk A/S, Søborg, Denmark.
⁶ Division of Cardiac Surgery, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.
⁷ Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Cardiovascular Diseases / diagnosis
Cardiovascular Diseases / epidemiology*
Cardiovascular Diseases / prevention & control
Cardiovascular System / drug effects*
Diabetes Mellitus, Type 2 / diagnosis
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / epidemiology
Diabetic Angiopathies / diagnosis
Diabetic Angiopathies / epidemiology*
Drug Therapy, Combination
Female
Hospitalization / statistics & numerical data
Humans
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use
Liraglutide / administration & dosage
Liraglutide / pharmacology*
Male
Metformin / administration & dosage*
Middle Aged
Prevalence
Prognosis
Randomized Controlled Trials as Topic / statistics & numerical data
Retrospective Studies
Treatment Outcome

Substances

Hypoglycemic Agents
Liraglutide
Metformin

Associated data

ClinicalTrials.gov/NCT01179048

Grants and funding