New findings useful for clinical practice using swept-source optical coherence tomography angiography in the follow-up of active ocular toxoplasmosis

João Rafael de Oliveira Dias; Camila Campelo; Eduardo Amorim Novais; Gabriel Costa de Andrade; Paula Marinho; Yusláy Fernández Zamora; Luciana Finamor Peixoto; Maurício Maia; Heloísa Nascimento; Rubens Belfort Jr

doi:10.1186/s40942-020-00231-2

New findings useful for clinical practice using swept-source optical coherence tomography angiography in the follow-up of active ocular toxoplasmosis

Int J Retina Vitreous. 2020 Jul 8:6:30. doi: 10.1186/s40942-020-00231-2. eCollection 2020.

Authors

João Rafael de Oliveira Dias^{1

2

3}, Camila Campelo^{1

2}, Eduardo Amorim Novais^{1

2}, Gabriel Costa de Andrade^{1

2}, Paula Marinho^{1

2}, Yusláy Fernández Zamora^{1

2}, Luciana Finamor Peixoto^{1

2}, Maurício Maia^{1

2}, Heloísa Nascimento^{1

2}, Rubens Belfort Jr^{1

2}

Affiliations

¹ Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, SP Brazil.
² Vision Institute, São Paulo, SP Brazil.
³ Rua Marechal Bormann, 243-E., Chapecó, SC 89802-120 Brazil.

Abstract

Background: Ocular toxoplasmosis is one of the most common causes of intraocular inflammation and posterior uveitis in immunocompetent patients. This paper aims to investigate swept-source optical coherence tomography angiography (SS-OCTA) findings in eyes with active toxoplasmic retinochoroiditis.

Methods: This case series was conducted from November 2017 through October 2019 in two Brazilian centers. 15 eyes of 15 patients with active toxoplasmic retinochoroiditis were included, and were imaged at baseline and after at least 4 weeks of follow-up. All patients underwent ophthalmic examinations and multimodal imaging including SS-OCT and SS-OCTA before and after treatment of ocular toxoplasmosis. The differential diagnoses included toxoplasmosis, syphilis, and human immunodeficiency virus, which were eliminated through serologic and clinical evaluations.

Results: All 15 patients presented with positive anti-Toxoplasma gondii immunoglobulin G titers and three also presented with positive anti-T. gondii immunoglobulin M titers. The mean age at examination was 32.4 years ± 12.7 years (range 15-59 years). Sixty percent of the patients were female. In all eyes, the inner retinal layers were abnormally hyperreflective with full-thickness disorganization of the retinal reflective layers at the site of the active toxoplasmic retinochoroiditis. At baseline, 80% of eyes had focal choroidal thickening beneath the retinitis area, and all eyes had a choroidal hyporeflective signal. Before treatment, SS-OCTA showed no OCTA decorrelation signal next to the lesion site in all eyes, and flow signal improvement was noticed after treatment. Three eyes presented with intraretinal vascular abnormalities during follow-up. SS-OCTA showed retinal neovascularization in one patient and a presumed subclinical choroidal neovascular membrane in another patient.

Conclusions: SS-OCT and SS-OCTA are useful for assessing unexpected structural and vascular retinal and choroidal changes in active and post-treatment toxoplasmic retinochoroiditis and these findings are useful for clinical practice.

Keywords: Ocular toxoplasmosis; Optical coherence tomography angiography; Toxoplasmic retinochoroiditis.