We reviewed the clinical efficacy of chloroquine for Plasmodium vivax malaria, the changing trend of parasite clearance time, and fever clearance time during 2000-2016 in South Korea. Median parasite clearance time and fever clearance time increased significantly over the study period. Chloroquine was mostly underdosed when used to treat P. vivax malaria.
Keywords: Chloroquine; Plasmodium vivax; South Korea; fever clearance time; hydroxychloroquine; malaria; parasite clearance time; parasites; primaquine; retrospective studies.