Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

J Biomater Appl. 2021 Jul;36(1):55-75. doi: 10.1177/0885328220952250. Epub 2020 Aug 25.

Abstract

Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

Keywords: Electrospinning; biodegradation; periodontal regeneration; scaffold; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents
  • Biocompatible Materials*
  • Gene Transfer Techniques
  • Humans
  • Nanoparticles
  • Periodontal Diseases / therapy
  • Periodontal Ligament
  • Periodontitis / therapy
  • Periodontium* / pathology
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*
  • Wound Healing

Substances

  • Anti-Infective Agents
  • Biocompatible Materials