Delirium in liver transplantation candidates: discriminant analysis of multiple test variables

Biol Psychiatry. 1988 May;24(1):3-14. doi: 10.1016/0006-3223(88)90116-3.

Abstract

We report the results of electroencephalograms, Mini-Mental State exam, Trailmaking Tests A and B, and serum albumin levels in 108 consecutive liver transplantation candidates. We compared test results to a clinical DSM-III diagnosis of delirium. Although each variable could differentiate between the two groups (delirium n = 18; nondelirium n = 90) at a statistically significant level, a discriminant analysis involving either all variables or only three particular variables (Trailmaking B, EEG code, and albumin) resulted in the highest specificity (97.8%) and sensitivity (83.3%), with a correct classification of 95.4% of subjects. The analysis also generates an equation that can be applied to clinical situations to enhance the accurate recognition of delirium. In addition, to explain abnormal Trailmaking B scores and/or EEGs in subjects who did not otherwise meet DSM-III criteria for delirium, we suggest the presence of a "subclinical delirium."

MeSH terms

  • Adolescent
  • Adult
  • Delirium / diagnosis*
  • Electroencephalography
  • Female
  • Hepatic Encephalopathy / diagnosis*
  • Humans
  • Liver Diseases / surgery
  • Liver Transplantation*
  • Male
  • Manuals as Topic
  • Middle Aged
  • Neuropsychological Tests
  • Postoperative Complications / diagnosis*
  • Psychomotor Performance
  • Risk Factors
  • Serum Albumin / metabolism

Substances

  • Serum Albumin