Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)

Supinda Bunyavanich; Chantal Grant; Alfin Vicencio

doi:10.1001/jama.2020.17386

Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)

JAMA. 2020 Oct 20;324(15):1567-1568. doi: 10.1001/jama.2020.17386.

Authors

Supinda Bunyavanich¹, Chantal Grant², Alfin Vicencio²

Affiliations

¹ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
² Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.

Abstract

This cross-sectional study used nasal epithelium collected in 2015-2018 to compare expression of TMPRSS2, a facilitator of SARS-CoV-2 viral entry and spread, among Asian, Black, Latino, and White patients as well as patients of mixed race/ethnicity within a New York City health system.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Adult
Asthma / complications
Asthma / metabolism
Black or African American
COVID-19 / transmission*
Child
Child, Preschool
Cross-Sectional Studies
Ethnicity
Female
Gene Expression*
Humans
Linear Models
Male
Middle Aged
Nasal Mucosa / metabolism*
Racial Groups
Risk Factors
Serine Endopeptidases / genetics*
Serine Endopeptidases / metabolism
Young Adult

Substances

Serine Endopeptidases
TMPRSS2 protein, human

Grants and funding

R01 AI118833/AI/NIAID NIH HHS/United States