Clostridioides difficile: Sometimes It Pays To Be Difficult

Matthew L Jenior; Jason A Papin

doi:10.1016/j.chom.2020.08.010

Clostridioides difficile: Sometimes It Pays To Be Difficult

Cell Host Microbe. 2020 Sep 9;28(3):358-359. doi: 10.1016/j.chom.2020.08.010.

Authors

Matthew L Jenior¹, Jason A Papin²

Affiliations

¹ Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
² Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Medicine, Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA. Electronic address: papin@virginia.edu.

PMID: 32910918
DOI: 10.1016/j.chom.2020.08.010

Abstract

In this issue of Cell Host & Microbe, publications from Bushman et al. (2020) and Knippel et al. (2020) outline elements of host epithelial damage or inflammation that Clostridioides difficile subverts, enabling continued growth. These mechanisms provide insight into how this important pathogen influences the gut environment to promote its metabolic strategy during infection.

Publication types

Comment

MeSH terms

Clostridiales
Clostridioides difficile*
Clostridium Infections*
Heme
Humans
Oxidative Stress

Substances

Heme