A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Angkana T Huang; Bernardo Garcia-Carreras; Matt D T Hitchings; Bingyi Yang; Leah C Katzelnick; Susan M Rattigan; Brooke A Borgert; Carlos A Moreno; Benjamin D Solomon; Luke Trimmer-Smith; Veronique Etienne; Isabel Rodriguez-Barraquer; Justin Lessler; Henrik Salje; Donald S Burke; Amy Wesolowski; Derek A T Cummings

doi:10.1038/s41467-020-18450-4

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Nat Commun. 2020 Sep 17;11(1):4704. doi: 10.1038/s41467-020-18450-4.

Authors

Angkana T Huang^#^{1

2

3}, Bernardo Garcia-Carreras^#^{1

2}, Matt D T Hitchings^#^{1

2}, Bingyi Yang^#^{1

2}, Leah C Katzelnick^#^{1

2}, Susan M Rattigan^{1

2}, Brooke A Borgert^{1

2}, Carlos A Moreno^{1

2}, Benjamin D Solomon⁴, Luke Trimmer-Smith^{1

2}, Veronique Etienne^{2

5}, Isabel Rodriguez-Barraquer⁶, Justin Lessler⁷, Henrik Salje^{1

8

9}, Donald S Burke¹⁰, Amy Wesolowski⁷, Derek A T Cummings^{11

12}

Affiliations

¹ Department of Biology, University of Florida, Gainesville, FL, USA.
² Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
³ Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
⁴ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
⁵ Department of Comparative, Diagnostic & Population Medicine, University of Florida, Gainesville, FL, USA.
⁶ Division of HIV, ID, and Global Medicine, University of California, San Francisco, CA, USA.
⁷ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁸ Department of Genetics, University of Cambridge, Cambridge, UK.
⁹ Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France.
¹⁰ Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
¹¹ Department of Biology, University of Florida, Gainesville, FL, USA. datc@ufl.edu.
¹² Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. datc@ufl.edu.

^# Contributed equally.

Abstract

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Antibodies, Viral / immunology*
Betacoronavirus / immunology*
COVID-19
Coronavirus Infections / immunology*
Coronavirus Infections / therapy
Cross Reactions
Databases, Factual
Humans
Immunization, Passive
Immunoglobulin Isotypes / immunology
Middle East Respiratory Syndrome Coronavirus / immunology
Pandemics
Pneumonia, Viral / immunology*
Pneumonia, Viral / therapy
SARS-CoV-2
Seroepidemiologic Studies

Substances

Antibodies, Viral
Immunoglobulin Isotypes

Abstract

Publication types

MeSH terms

Substances

Grants and funding