Head and neck cancer patient-derived xenograft models - A systematic review

Lauren F Schuch; Felipe M Silveira; Vivian P Wagner; Gabriell B Borgato; Guilherme Z Rocha; Rogerio M Castilho; Pablo A Vargas; Manoela D Martins

doi:10.1016/j.critrevonc.2020.103087

Head and neck cancer patient-derived xenograft models - A systematic review

Crit Rev Oncol Hematol. 2020 Nov:155:103087. doi: 10.1016/j.critrevonc.2020.103087. Epub 2020 Sep 1.

Authors

Lauren F Schuch¹, Felipe M Silveira¹, Vivian P Wagner¹, Gabriell B Borgato¹, Guilherme Z Rocha¹, Rogerio M Castilho², Pablo A Vargas¹, Manoela D Martins³

Affiliations

¹ Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, Piracicaba, SP, Brazil.
² Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109-1078, United States; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, 48109, United States.
³ Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, Piracicaba, SP, Brazil; Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: manomartins@gmail.com.

PMID: 32992152
DOI: 10.1016/j.critrevonc.2020.103087

Abstract

Background: Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.

Methods: An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.

Results: 63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.

Conclusion: HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC.

Keywords: Animal models; Head and neck neoplasms; Preclinical drug evaluation; Translational medical research; Xenograft model antitumor assays.

Publication types

Review
Systematic Review

MeSH terms

Animals
Carcinoma, Squamous Cell*
Disease Models, Animal
Head and Neck Neoplasms*
Heterografts
Humans
Mice
Xenograft Model Antitumor Assays