An ace model for SARS-CoV-2 infection

J Exp Med. 2020 Dec 7;217(12):e20201748. doi: 10.1084/jem.20201748.

Abstract

Developing effective in vivo models for SARS-CoV-2 infection is crucial for mechanistic studies of COVID-19 disease progression. In this issue of JEM, Israelow et al. (https://doi.org/10.1084/jem.20201241) generate a model that supports SARS-CoV-2 infection in mice, which they use to characterize type I IFN-driven pulmonary inflammation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections*
  • Interferon Type I*
  • Mice
  • Pandemics*
  • Pneumonia, Viral*
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome*

Substances

  • Interferon Type I