Disseminated Nannizziopsis Infection in an Adolescent With a STAT1 Mutation

Zachary M Most; Tiffany Lieu; Laura Filkins; Rory Nicolaides; Dinesh Rakheja; Andrew Gelfand; Jeffrey Kahn

doi:10.1093/ofid/ofaa390

Disseminated Nannizziopsis Infection in an Adolescent With a STAT1 Mutation

Open Forum Infect Dis. 2020 Aug 27;7(9):ofaa390. doi: 10.1093/ofid/ofaa390. eCollection 2020 Sep.

Authors

Zachary M Most¹, Tiffany Lieu², Laura Filkins³, Rory Nicolaides⁴, Dinesh Rakheja³, Andrew Gelfand⁵, Jeffrey Kahn^{1

6}

Affiliations

¹ University of Texas Southwestern Medical Center, Department of Pediatrics, Division of Infectious Disease, Dallas, Texas, USA.
² University of Texas Southwestern Medical Center, Department of Pediatrics, Division of Hospital Medicine, Dallas, Texas, USA.
³ University of Texas Southwestern Medical Center, Department of Pathology, Dallas, Texas, USA.
⁴ University of Texas Southwestern Medical Center, Department of Pediatrics, Division of Allergy and Immunology, Dallas, Texas, USA.
⁵ University of Texas Southwestern Medical Center, Department of Pediatrics, Division of Respiratory Medicine, Dallas, Texas, USA.
⁶ University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, Texas, USA.

Abstract

An adolescent with failure to thrive developed cuboid bone osteomyelitis and brain abscesses. Mold isolated from both locations was identified by universal genetic sequencing as Nannizziopsis spp, which is typically a pathogen of reptiles. The patient was subsequently diagnosed with a STAT1 mutation and was successfully treated.

Keywords: Nannizziopsis; STAT1; fungal infections; immunocompromised host; voriconazole.