Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling

Signal Transduct Target Ther. 2020 Oct 6;5(1):221. doi: 10.1038/s41392-020-00332-2.

Authors

Yaoxing Wu^#¹, Ling Ma^#¹, Zhen Zhuang^#², Sihui Cai^#¹, Zhiyao Zhao¹, Lingli Zhou¹, Jing Zhang³, Pei-Hui Wang³, Jincun Zhao⁴, Jun Cui⁵

Affiliations

¹ MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, Guangdong, China.
² State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
³ Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China.
⁴ State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojincun@gird.cn.
⁵ MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, Guangdong, China. cuij5@mail.sysu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / immunology
Betacoronavirus / genetics*
Betacoronavirus / immunology
Cell Line, Tumor
Coronavirus 3C Proteases
Cysteine Endopeptidases / genetics*
Cysteine Endopeptidases / immunology
Cytokines / genetics
Cytokines / immunology
DEAD Box Protein 58 / genetics
DEAD Box Protein 58 / immunology
Epithelial Cells / immunology
Epithelial Cells / virology
Gene Expression Regulation
Hepatocytes / immunology
Hepatocytes / virology
Host-Pathogen Interactions / genetics*
Host-Pathogen Interactions / immunology
Humans
Interferon Regulatory Factor-3 / genetics
Interferon Regulatory Factor-3 / immunology
Interferon-alpha / genetics*
Interferon-alpha / immunology
Interferon-beta / genetics*
Interferon-beta / immunology
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / immunology
RNA-Binding Proteins / genetics
RNA-Binding Proteins / immunology
Receptors, Immunologic
SARS-CoV-2
STAT1 Transcription Factor / genetics
STAT1 Transcription Factor / immunology
Signal Transduction / genetics*
Signal Transduction / immunology
Ubiquitins / genetics
Ubiquitins / immunology
Viral Nonstructural Proteins / genetics*
Viral Nonstructural Proteins / immunology

Substances

Adaptor Proteins, Signal Transducing
Cytokines
IFIT1 protein, human
IRF3 protein, human
Interferon Regulatory Factor-3
Interferon-alpha
MAVS protein, human
RNA-Binding Proteins
Receptors, Immunologic
STAT1 Transcription Factor
STAT1 protein, human
Ubiquitins
Viral Nonstructural Proteins
ISG15 protein, human
Interferon-beta
Protein Serine-Threonine Kinases
TBK1 protein, human
Cysteine Endopeptidases
Coronavirus 3C Proteases
RIGI protein, human
DEAD Box Protein 58

Grants and funding

31870862/National Natural Science Foundation of China (National Science Foundation of China)/International