Abstract
We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012-February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoviridae / isolation & purification
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Adolescent
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Adult
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Aged
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Child
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Child, Preschool
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Clostridioides difficile / isolation & purification
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Clostridium Infections / epidemiology*
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Coinfection* / diagnosis
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Coinfection* / epidemiology
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Community-Acquired Infections / epidemiology*
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Feces / microbiology
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Feces / virology
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Female
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Humans
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Male
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Middle Aged
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Norovirus / isolation & purification
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Rotavirus / isolation & purification
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Sapovirus / isolation & purification
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United States / epidemiology
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Virus Diseases* / diagnosis
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Virus Diseases* / epidemiology
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Young Adult
Grants and funding
This work was funded by the Centers for Disease Control and Prevention, which had a role in study design, date collection and analysis, decision to publish, and preparation of the manuscript.