An inventory of lysosomal ABC transporters

FEBS Lett. 2020 Dec;594(23):3965-3985. doi: 10.1002/1873-3468.13967. Epub 2020 Nov 28.

Abstract

ABC transporters fulfill diverse physiological functions in different cellular localizations ranging from the plasma membrane to intracellular membranous compartments. Several ABC transporters have been spotted in the endolysosomal system, which consists of endosomes, autophagosomes, lysosomes, and lysosome-related organelles. In this review, we present an overview of lysosomal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6, ABCB9, and ABCD4, discussing their trafficking routes, putative substrates, potential physiological functions, and associated diseases. In addition, we offer a critical evaluation of the literature linking ABC transporters to lysosomal drug sequestration, examining pitfalls associated with in vitro models of drug resistance.

Keywords: ABC transporters; cholesterol; drug resistance; endolysosomal system; lipid; lysosomes; peptide transport; surfactant; trafficking; vitamin B12.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Humans
  • Lysosomes / metabolism*
  • Pharmaceutical Preparations / metabolism
  • Vitamin B 12 / metabolism

Substances

  • ABCA2 protein, human
  • ABCA3 protein, human
  • ABCA5 protein, human
  • ABCB9 protein, human
  • ABCD4 protein, human
  • ATP-Binding Cassette Transporters
  • Pharmaceutical Preparations
  • Vitamin B 12