A systematic review on phytochemicals for the treatment of dengue

Phytother Res. 2021 Apr;35(4):1782-1816. doi: 10.1002/ptr.6917. Epub 2020 Oct 28.

Abstract

Dengue fever is prevalent in subtopic regions, producing mortality and morbidity worldwide, which have been of major concern to different governments and World Health Organization. The search of new anti-dengue agents from phytochemicals was assumed to be highly emergent in past. The phytochemicals have been used in wide distribution of vector ailments such as malaria. The demand of the phytochemicals is based on the medicines which are mostly considered to be safer, less harmful than synthetic drugs and nontoxic. This review mentions majorly about the phytochemicals potentially inhibiting dengue fever around the world. The phytochemicals have been isolated from different species, have potential for the treatment of dengue. Different crude extracts and essential oils obtained from different species showed a broad activity against different phytochemicals. The current studies showed that natural products represent a rich source of medicines toward the dengue fever. Furthermore, ethnobotanical surveys and laboratory investigation established identified natural plants species in the development of drug discovery to control the dengue fever.

Keywords: crude extracts; dengue fever; essential oils; natural products; phytochemicals.

Publication types

  • Systematic Review

MeSH terms

  • Animals
  • Dengue / drug therapy*
  • Humans
  • Phytochemicals / pharmacology
  • Phytochemicals / therapeutic use*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*

Substances

  • Phytochemicals
  • Plant Extracts