The sprint start in athletics is strictly controlled to ensure the fairness of competition. World athletics (WA)-certified start information systems (SIS) record athletes' response times in competition to ensure that no athletes gain an unfair advantage by responding in < 100 ms after the start signal. This critical review examines the legitimacy of the 100 ms rule, the factors that affect response times and the technologies and rules that support the regulation of the start in competition. The review shows that several SIS use different technologies to deliver the start signal and record response time (RT). The lack of scientific evidence about the definition of the 100 ms false start threshold by the WA is criticized in the literature and the 100 ms rule is challenged. SIS technologies, expertise and sex appear to affect the RT detected in competition. A lack of standardization in event detection has led to validity and reliability problems in RT determination. The onset of the foot response on the blocks is currently used to assess RT in athletics via block-mounted sensors; however, research shows that the onset of arm force reaction is the first detectable biomechanical event in the start. Further research and development should consider whether the onset of arm force can be used to improve the false start detection in competition. Further research is also needed to develop a precise understanding of the event sequence and motor control of the start to improve the SIS technology and rigorously determine the minimum limit of RT in the sprint start.