Synthetic peptide vaccine confers protection against murine malaria

J Exp Med. 1987 Nov 1;166(5):1591-6. doi: 10.1084/jem.166.5.1591.

Abstract

A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Protozoan / biosynthesis*
  • Antibodies, Protozoan / immunology
  • Antibody Affinity
  • Antigens, Protozoan / immunology*
  • Antigens, Surface / immunology*
  • Immunization
  • Malaria / prevention & control*
  • Mice
  • Mice, Inbred A
  • Peptides / immunology
  • Plasmodium berghei / immunology*
  • Protozoan Proteins*
  • Rats
  • Rats, Inbred BN
  • Tetanus Toxoid / immunology
  • Vaccines, Synthetic / immunology*

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Antigens, Surface
  • Peptides
  • Protozoan Proteins
  • Tetanus Toxoid
  • Vaccines, Synthetic
  • circumsporozoite protein, Protozoan