Objective: To evaluate the effect and safety of laparoscopic cholecystectomy (LC) on the treatment of patients with gallbladder cancer (GBC), compared with patients undergoing open cholecystectomy (OC). Methods: PubMed, EMBASE, Web of Science, CNKI, CQVIP and WANFANG DATA and the Cochrane Library were searched for all Chinese and English literatures of randomized or non-randomized concurrent controlled trials of OC and LC treatment of GBC from the database establishment to March 2020. Two reviewers selected the studies according to inclusion and exclusion criteria, extracted the data, and then a meta-analysis was subsequently performed by the RevMan 5.3 software provided by the Cochrane Library. Results: A total of 15 studies (1 074 patients) including 14 retrospective studies and 1 prospective study met the inclusion criteria. The meta-analysis showed that compared with OC, LC has significant short-term efficacy in the treatment of patients with gallbladder cancer, including shorter operation time (mean difference (MD) =-18.78, 95% confidence interval (CI) : -36.68-0.88; P=0.04), less intraoperative blood loss (MD=-166.57, 95%CI: -248.51--84.63; P<0.000 1), shorter post-operative hospital stays (MD=-5.00, 95%CI: -6.43--3.57; P<0.000 1), less complication rate (OR=0.47, 95%CI: 0.28-0.79; P=0.004), but there was no significant difference on the aspects of recurrence rate (OR=0.48, 95%CI: 0.21-1.11; P=0.09), 5-year overall survival (HR=0.93, 95%CI: 0.54-1.61, I2=33.5%, P=0.198) and long-term survival. Conclusion: Whether it is radical cholecystectomy (RC) or simple cholecystectomy (SC), the short-term efficacy of LC is more significant than that of OC, and the long-term survival rate has no significant statistical difference. Limited by the quality of literature and experiments, the above conclusions still need to be supported by higher quality research.
目的： 通过与开放性胆囊癌手术（OC）的比较,系统性评价腹腔镜胆囊手术（LC）在胆囊癌患者中的疗效和安全性。 方法： 计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方和维普等数据库，收集OC和LC治疗胆囊癌随机或非随机同期对照试验的所有中英文文献，检索时限为建库至2020年3月。由两名评价者按照纳入与排除标准选择文献、提取胆囊癌患者资料后，采用Cochrane library提供的软件RevMan 5.3和Stata13.1软件行meta分析。 结果： 最终纳入了较新的15项研究，包括14项回顾性研究和1项前瞻性研究，共1 074例患者。其中接受LC的胆囊癌患者528例，接受OC的患者546例。分析后得出：相比于开放根治性切除术（ORC）,腹腔镜根治性切除术（LRC）治疗胆囊癌患者的短期疗效显著，包括手术时间明显缩短（MD=-18.78，95%CI：-36.68~-0.88，P=0.04）、术中出血量明显减少（MD=-166.57，95%CI：-248.51~-84.63，P<0.000 1）、术后住院时间明显缩短（MD=-5.00，95%CI=-6.43~-3.57，P<0.000 1）、并发症发生率更低（OR=0.47，95%CI：0.28~0.79，P=0.004）,但在长期生存率方面，差异无统计学意义，包括复发率（OR=0.48，95%CI=0.21~1.11，P=0.09）和5年生存率（HR=0.93，95%CI：0.54~1.61，I2=33.5%,P=0.198）。 结论： 无论是根治性手术（RC）还是单纯胆囊切除术（SC）,相比于传统的OC，LC的短期疗效更显著，长期生存率差异无统计学意义。受文献质量和试验的限制，上述结论仍需要更高质量的研究予以支持。.
Keywords: Gallbladder neoplasms; Laparoscopes; Laparoscopic cholecystectomy; Meta-analysis.