Alteration in cerebrospinal fluid (CSF) markers associated with α-synucleinopathies

Eur Arch Psychiatry Clin Neurosci. 2021 Aug;271(5):999-1000. doi: 10.1007/s00406-020-01212-0. Epub 2020 Nov 22.

Abstract

Rapid eye movement sleep behavior disorder (RBD) is linked to other α-synucleinopathies such as Parkinson's disease and Lewy body dementia. It is essential to consider and exclude RBD while studying CSF markers in the latter two to avoid confounding bias and improve test results' specificity.

Keywords: Cerebrospinal fluid; Lewy body dementia; Parkinson disease; REM sleep behavior disorder.

Publication types

  • Letter

MeSH terms

  • Biomarkers / metabolism
  • Cerebrospinal Fluid* / metabolism
  • Humans
  • Lewy Body Disease / cerebrospinal fluid
  • Lewy Body Disease / diagnosis
  • Parkinson Disease / cerebrospinal fluid
  • Parkinson Disease / diagnosis
  • REM Sleep Behavior Disorder / cerebrospinal fluid
  • REM Sleep Behavior Disorder / diagnosis
  • Synucleinopathies* / cerebrospinal fluid

Substances

  • Biomarkers