Effect of soy products and isoflavones on oxidative stress parameters: A systematic review and meta-analysis of randomized controlled trials

Mojgan Morvaridzadeh; Seyed Mostafa Nachvak; Shahram Agah; Mahdi Sepidarkish; Fereshteh Dehghani; Mehran Rahimlou; Ana Beatriz Pizarro; Javad Heshmati

doi:10.1016/j.foodres.2020.109578

Effect of soy products and isoflavones on oxidative stress parameters: A systematic review and meta-analysis of randomized controlled trials

Food Res Int. 2020 Nov:137:109578. doi: 10.1016/j.foodres.2020.109578. Epub 2020 Jul 21.

Authors

Mojgan Morvaridzadeh¹, Seyed Mostafa Nachvak¹, Shahram Agah², Mahdi Sepidarkish³, Fereshteh Dehghani⁴, Mehran Rahimlou⁵, Ana Beatriz Pizarro⁶, Javad Heshmati⁷

Affiliations

¹ Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
³ Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran.
⁴ Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
⁵ Nutrition Department, Faculty of Paramedicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
⁶ Department of Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia. Electronic address: a.pizarro@javeriana.edu.co.
⁷ Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: javad.heshmati@gmail.com.

PMID: 33233189
DOI: 10.1016/j.foodres.2020.109578

Abstract

Soy products and isoflavones intake have been shown to exert antioxidant effects. There are several randomized control trials (RCTs) that evaluated the effect of soy products intake on oxidative stress (OS) parameters. The aim of the present systematic review and meta-analysis was to summarize the results of RCTs evaluating the effect of soy products and isoflavones intake on OS parameters. Randomized trials that assessed the effect of soy products and isoflavones intake on OS parameters in adults were identified through searching in electronic databases: Cochrane clinical trial center, Embase, PubMed, Scopus, and Web of Sciences up to April 2020. Random effects model was used to calculate the effects sizes of soy intake on OS parameters. Twenty-four trials with 1,852 participants were eligible and were included in the meta-analysis which measured OS parameters. Soy intake compared to control group significantly reduced MDA levels (SMD: -0.53; 95% CI: -0.86, -0.19; I² = 88.3%), increased GSH levels (SMD: 0.51; 95% CI: 0.13, 0.88; I² = 72.4%), SOD activity (SMD: 0.53; 95% CI: 0.08, 0.99; I² = 84.1%), TAC (SMD: 0.54; 95% CI: 0.27, 0.82; I² = 49.3%) and TRAP (SMD: 1.74; 95% CI: 0.82, 2.65; I² = 81.3%) significantly compared to control group. Soy products and isoflavones intake are effective in improving OS parameters in adults compared with controls; thus, it could be a valuable advise to control OS progress in chronic diseases.

Keywords: Isoflavones; Malondialdehyde; Oxidative stress; Soy.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Adult
Glycine max
Humans
Isoflavones*
Nutrients
Oxidative Stress
Randomized Controlled Trials as Topic

Substances

Isoflavones