miRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma

Zeng-Hong Wu; Yi Zhong; Tao Zhou; Hong-Jun Xiao

doi:10.1016/j.ygeno.2020.12.002

miRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma

Genomics. 2021 Jan;113(1 Pt 1):135-141. doi: 10.1016/j.ygeno.2020.12.002. Epub 2020 Dec 3.

Authors

Zeng-Hong Wu¹, Yi Zhong², Tao Zhou³, Hong-Jun Xiao⁴

Affiliations

¹ Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
² Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: entzt2013@hust.edu.cn.
⁴ Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: xhjent@163.com.

PMID: 33279650
DOI: 10.1016/j.ygeno.2020.12.002

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract. The loss and gain of miRNA function promote cancer development through various mechanisms. RNA sequencing (RNA-seq) and miRNAs sequencing data from the Cancer Genome Atlas (TCGA) was used to show the dysfunctional miRNAs microenvironment and to provide useful biomarkers for miRNAs therapy. Seven miRNAs were found to be independent prognostic factors of HNSCC patients in the training cohort. A total of 60 target genes for these miRNAs were predicted. Nine target genes (CDCA4, CXCL14, FLNC, KLF7, NBEAL2, P4HA1, PFKM, PFN2 and SEPPINE1) were correlated with patient's overall survival (OS) outcomes. We identified novel miRNAs markers for the prognosis of head and neck squamous cell carcinoma.

Keywords: Head and neck squamous cell carcinoma; Prognosis; TCGA; miRNAs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Blood Proteins / genetics
Blood Proteins / metabolism
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / pathology
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
Chemokines, CXC / genetics
Chemokines, CXC / metabolism
Female
Filamins / genetics
Filamins / metabolism
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / metabolism
Head and Neck Neoplasms / pathology
Humans
Kruppel-Like Transcription Factors / genetics
Kruppel-Like Transcription Factors / metabolism
Male
MicroRNAs / genetics*
MicroRNAs / metabolism
Middle Aged
Phosphofructokinase-1, Muscle Type / genetics
Phosphofructokinase-1, Muscle Type / metabolism
Plasminogen Activator Inhibitor 1 / genetics
Plasminogen Activator Inhibitor 1 / metabolism
Procollagen-Proline Dioxygenase / genetics
Procollagen-Proline Dioxygenase / metabolism
Profilins / genetics
Profilins / metabolism

Substances

Biomarkers, Tumor
Blood Proteins
CDCA4 protein, human
CXCL14 protein, human
Cell Cycle Proteins
Chemokines, CXC
FLNC protein, human
Filamins
KLF7 protein, human
Kruppel-Like Transcription Factors
MicroRNAs
NBEAL2 protein, human
PFN2 protein, human
Plasminogen Activator Inhibitor 1
Profilins
P4HA1 protein, human
Procollagen-Proline Dioxygenase
Phosphofructokinase-1, Muscle Type
PFKM protein, human