Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: a cross-sectional study

BMJ Open. 2020 Dec 7;10(12):e042122. doi: 10.1136/bmjopen-2020-042122.

Abstract

Introduction: Asymptomatic carriers (AC) of the new SARS-CoV-2 represent an important source of spread for COVID-19. Early diagnosis of these cases is a powerful tool to control the pandemic. Our objective was to characterise patients with AC status and identify associated sociodemographic factors.

Methods: Using a cross-sectional design and the national database of daily occurrence of COVID-19, we characterised both socially and demographically all ACs. Additional correspondence analysis and logistic regression model were performed to identify characteristics associated with AC state (OR, 95% CI).

Results: 76.162 ACs (12.1%; 95% CI 12.0% to 12.2%) were identified, mainly before epidemiological week 35. Age≤26 years (1.18; 1.09 to 1.28), male sex (1.51; 1.40 to 1.62), cases imported from Venezuela, Argentina, Brazil, Germany, Puerto Rico, Spain, USA or Mexico (12.6; 3.03 to 52.5) and autochthonous cases (22.6; 5.62 to 91.4) increased the risk of identifying ACs. We also identified groups of departments with moderate (1.23; 1.13 to 1.34) and strong (19.8; 18.6 to 21.0) association with ACs.

Conclusion: Sociodemographic characteristics strongly associated with AC were identified, which may explain its epidemiological relevance and usefulness to optimise mass screening strategies and prevent person-to-person transmission.

Keywords: epidemiology; infectious diseases; virology.

MeSH terms

  • Adult
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • COVID-19 / transmission
  • Carrier State / diagnosis
  • Carrier State / epidemiology*
  • Carrier State / transmission
  • Colombia
  • Cross-Sectional Studies
  • Databases, Factual
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • SARS-CoV-2