(1) Background: The responsibility of vaccinating children lies with their parents. Therefore, parents' attitudes, knowledge and perceptions towards vaccination are of great importance as it drives their actions for timely and complete immunisation. This systematic literature review was conducted to gain a better understanding of parents' knowledge, attitudes and perceptions regarding childhood vaccination in Saudi Arabia. (2) Methods: A comprehensive systematic literature review was conducted to identify evidence demonstrating parents' knowledge, attitudes and perceptions on childhood vaccination in Saudi Arabia. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines were used for this review. (3) Results: Nine studies were subsequently included in this systematic review. (4) Conclusions: All the individual reports in the literature do not cover the entire nation of Saudi Arabia, indicating the necessity of more comprehensive investigations so that the government and policymakers can develop versatile fact-based policies for the well-being of future generations.
Keywords: attitude; childhood vaccination; children; immunisation in Saudi Arabia; knowledge; parental perceptions; parents; vaccine.