The effect of green tea on prostate specific antigen (PSA): A systematic review and meta-analysis of randomized controlled trials

Elham Sharifi-Zahabi; Fatemeh Hajizadeh-Sharafabad; Hadi Abdollahzad; Afsaneh Dehnad; Farzad Shidfar

doi:10.1016/j.ctim.2020.102659

The effect of green tea on prostate specific antigen (PSA): A systematic review and meta-analysis of randomized controlled trials

Complement Ther Med. 2021 Mar:57:102659. doi: 10.1016/j.ctim.2020.102659. Epub 2021 Jan 2.

Authors

Elham Sharifi-Zahabi¹, Fatemeh Hajizadeh-Sharafabad², Hadi Abdollahzad³, Afsaneh Dehnad⁴, Farzad Shidfar⁵

Affiliations

¹ Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
² Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Nutritional Sciences Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁴ Head of English Language Department, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran; Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Tehran, Iran.
⁵ Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: shidfar.f@iums.ac.ir.

PMID: 33400976
DOI: 10.1016/j.ctim.2020.102659

Abstract

Background: Prostate cancer is a major malignancy, affecting men, worldwide. The protective effect of green tea consumption on prostate cancer has been reported in several studies; however, the findings are equivocal.

Objective: The aim of this study was to evaluate the effects of green tea on PSA level, by conducting a systematic review and meta-analysis of randomized controlled trials.

Methods: We searched online databases, including PubMed, Scopus, and Web of Science, up to 11 Aug 2020, to obtain relevant publications. The publication search was not limited by language or date.

Results: A total of 2488 records were identified in the systematic search; from these, seven were included in the meta-analysis. The overall analysis showed no significant changes in PSA levels in subjects treated with green tea, (WMD: ‒0.60 ng/mL; 95 % CI: ‒1.32, 0.12 ng/mL; P = 0.104, I² = 93.80 %, P heterogeneity<0.001). Subgroup analysis based on geographical location showed that green tea significantly reduced PSA level in the USA population (WMD: ‒1.02 pg/mL, 95 % CI: ‒1.30, ‒0.73, P < 0.001) compared to non-USA populations (WMD: ‒0.22 pg/mL, 95 % CI: ‒0.95, 0.50, P = 0.539) (P < 0.001).

Conclusion: The results of this review show that green tea has no significant effect on PSA level. However, due to the heterogeneity among studies more consistent clinical trials, with larger sample sizes are required.

Keywords: Catechin; Green tea; PSA; Prostate cancer; Prostate specific antigen.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Humans
Kallikreins*
Male
Plant Extracts
Prostate-Specific Antigen*
Prostatic Neoplasms* / drug therapy
Randomized Controlled Trials as Topic
Tea

Substances

Plant Extracts
Tea
KLK3 protein, human
Kallikreins
Prostate-Specific Antigen