Disseminated Toxoplasmosis in a Child Following Allogeneic Hematopoietic Cell Transplantation

Angelique E Boutzoukas; Ashleigh Kussman; Rajinder P S Bajwa; Christopher P Ouellette

doi:10.1093/jpids/piaa163

Disseminated Toxoplasmosis in a Child Following Allogeneic Hematopoietic Cell Transplantation

J Pediatric Infect Dis Soc. 2021 May 28;10(5):698-701. doi: 10.1093/jpids/piaa163.

Authors

Angelique E Boutzoukas¹, Ashleigh Kussman^{1

2}, Rajinder P S Bajwa^{1

2}, Christopher P Ouellette^{1

3}

Affiliations

¹ Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
² Division of Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
³ Division of Infectious Diseases and Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

PMID: 33452804
DOI: 10.1093/jpids/piaa163

Abstract

A 23-month old female with hypoplastic myelodysplastic syndrome underwent allogenic hematopoietic cell transplantation (HCT), complicated by development of acute exotropia. Bilateral chorioretinal scars and a ring enhancing brain lesion were identified in further workup. Disseminated toxoplasmosis post-allogeneic HCT was subsequently confirmed by serologic and polymerase chain reaction testing results.

Keywords: allogeneic; hematopoietic cell transplant; toxoplasmosis.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

Child
Child, Preschool
Female
Hematopoietic Stem Cell Transplantation*
Humans
Infant
Toxoplasmosis*
Transplantation, Homologous