EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease

Jian Li; Xiuzhi Yin; Aiwei Lin; Xiuzhen Nie; Liyan Liu; Shihua Liu; Na Li; Ping Wang; Shuangshuang Song; Shaoning Wang; Daoyan Xu

doi:10.1080/21645515.2020.1851129

EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease

Hum Vaccin Immunother. 2021 Jul 3;17(7):2097-2100. doi: 10.1080/21645515.2020.1851129. Epub 2021 Jan 31.

Authors

Jian Li¹, Xiuzhi Yin¹, Aiwei Lin¹, Xiuzhen Nie¹, Liyan Liu¹, Shihua Liu¹, Na Li¹, Ping Wang¹, Shuangshuang Song¹, Shaoning Wang¹, Daoyan Xu¹

Affiliation

¹ Infectious Diseases Department, Shandong University Qilu Children's Hospital, Jinan, China.

Abstract

In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in non-vaccinated (P = .028), which suggests that EV71 vaccine has a protective effect on the occurrence of encephalitis. But some EV71 vaccinated patients still developed into encephalitis showed that they had not produced protection or protection was weak against EV71-related encephalitis; the reasons require further investigation.

Keywords: EV71 vaccine; encephalitis; foot and mouth disease; hand; protective effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

China
Encephalitis* / epidemiology
Encephalitis* / prevention & control
Enterovirus A, Human*
Hand, Foot and Mouth Disease* / epidemiology
Hand, Foot and Mouth Disease* / prevention & control
Humans
Incidence
Infant
Vaccination

Grants and funding

This work was supported by the Science and Technology Planning Project of Jinan Health and Family Planning Commission (grant numbers: 2017-1-42).