Ceftriaxone is one of the most common antibiotics prescribed for hospitalized children in the United States. However, ceftriaxone is not dosed consistently. Sepsis/serious bacterial infection had high dosing variability. Dosing for central nervous system infection was frequently suboptimal. Future efforts should focus on optimizing and standardizing ceftriaxone dosing.
Keywords: antibiotic dosing; ceftriaxone; inpatient antimicrobial stewardship; therapeutic dosing; weight-based dosing.
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