In-Frame 12-Nucleotide Deletion within Open Reading Frame 3a in a SARS-CoV-2 Strain Isolated from a Patient Hospitalized with COVID-19

John A Lednicky; Kartikeya Cherabuddi; Massimiliano S Tagliamonte; Maha A Elbadry; Kuttichantran Subramaniam; Thomas B Waltzek; J Glenn Morris Jr

doi:10.1128/MRA.00137-21

In-Frame 12-Nucleotide Deletion within Open Reading Frame 3a in a SARS-CoV-2 Strain Isolated from a Patient Hospitalized with COVID-19

Microbiol Resour Announc. 2021 Feb 25;10(8):e00137-21. doi: 10.1128/MRA.00137-21.

Authors

John A Lednicky^{1

2}, Kartikeya Cherabuddi^{3

4}, Massimiliano S Tagliamonte^{3

5}, Maha A Elbadry^{3

2}, Kuttichantran Subramaniam^{3

6}, Thomas B Waltzek^{3

6}, J Glenn Morris Jr^{3

4}

Affiliations

¹ Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA jlednicky@phhp.ufl.edu.
² Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
³ Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
⁴ Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
⁵ Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
⁶ Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain UF-8, with an in-frame 12-nucleotide deletion within open reading frame 3a (ORF3a), was isolated from a 78-year-old COVID-19 patient in March 2020.