The effect of L-dopa on in vivo dopamine release from nigrostriatal bundle neurons

Brain Res. 1988 Apr 26;447(1):191-4. doi: 10.1016/0006-8993(88)90985-7.

Abstract

We have examined the impact of L-dihydroxyphenylalanine (L-DOPA) on the in vivo release of dopamine (DA) in rat striatum using carbon fiber voltammetry. L-DOPA caused a large increase in the DA released by nigrostriatal bundle stimulation. This was reduced by 94% in animals pretreated with intraventricular 6-hydroxydopamine. We conclude that L-DOPA increases depolarization-induced DA release from DA neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carbidopa / pharmacology
  • Corpus Striatum / drug effects
  • Corpus Striatum / physiology*
  • Dopamine / metabolism*
  • Electric Stimulation
  • Kinetics
  • Levodopa / pharmacology*
  • Male
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats
  • Reference Values
  • Substantia Nigra / drug effects
  • Substantia Nigra / physiology*

Substances

  • Levodopa
  • Carbidopa
  • Dopamine