Abstract
We have examined the impact of L-dihydroxyphenylalanine (L-DOPA) on the in vivo release of dopamine (DA) in rat striatum using carbon fiber voltammetry. L-DOPA caused a large increase in the DA released by nigrostriatal bundle stimulation. This was reduced by 94% in animals pretreated with intraventricular 6-hydroxydopamine. We conclude that L-DOPA increases depolarization-induced DA release from DA neurons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carbidopa / pharmacology
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Corpus Striatum / drug effects
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Corpus Striatum / physiology*
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Dopamine / metabolism*
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Electric Stimulation
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Kinetics
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Levodopa / pharmacology*
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Male
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Neurons / drug effects
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Neurons / physiology*
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Rats
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Reference Values
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Substantia Nigra / drug effects
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Substantia Nigra / physiology*
Substances
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Levodopa
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Carbidopa
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Dopamine