Abstract
Beyond blood pressure control, angiotensin receptor blockers reduce common injury mechanisms, decreasing excessive inflammation and protecting endothelial and mitochondrial function, insulin sensitivity, the coagulation cascade, immune responses, cerebrovascular flow, and cognition, properties useful to treat inflammatory, age-related, neurodegenerative, and metabolic disorders of many organs including brain and lung.
Keywords:
COVID-19; angiotensin receptor blockers; estrogen; inflammation; neuroprotection.
MeSH terms
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Angiotensin Receptor Antagonists / adverse effects
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Angiotensin Receptor Antagonists / therapeutic use*
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Angiotensin-Converting Enzyme Inhibitors / adverse effects
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
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Animals
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Anti-Inflammatory Agents / therapeutic use
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Antihypertensive Agents / therapeutic use
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Antiviral Agents / adverse effects
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Antiviral Agents / therapeutic use*
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COVID-19 / metabolism
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COVID-19 / physiopathology
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COVID-19 / virology
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COVID-19 Drug Treatment*
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Fibrinolytic Agents / therapeutic use
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Humans
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Renin-Angiotensin System / drug effects*
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SARS-CoV-2 / drug effects*
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SARS-CoV-2 / pathogenicity
Substances
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Angiotensin Receptor Antagonists
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Angiotensin-Converting Enzyme Inhibitors
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Anti-Inflammatory Agents
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Antihypertensive Agents
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Antiviral Agents
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Fibrinolytic Agents