A qualitative analysis of seven ivermectin formulations in South Africa

S Afr Med J. 2021 Feb 18;111(4):288-290. doi: 10.7196/SAMJ.2021.v111i4.15630.

Abstract

Some South African (SA) healthcare practitioners are promoting the prescription and use of products claiming to contain ivermectin for the treatment and/or prevention of COVID-19 in SA. This study qualitatively analysed seven samples of ivermectin formulations (5 tablet and 2 capsule formulations) being sold in SA for human use. The samples were analysed using a high-performance liquid chromatography instrument connected to a Sciex X500R quadrupole time-of-flight high-resolution mass spectrometer. The study found that all the samples had both the major homologues of ivermectin (B1a and B1b) and also that 4 out of the 5 tablet formulations tested had at least one additional undeclared active pharmaceutical ingredient.

MeSH terms

  • COVID-19 / epidemiology
  • COVID-19 Drug Treatment*
  • Capsules
  • Chromatography, High Pressure Liquid
  • Humans
  • Ivermectin / analysis*
  • Ivermectin / therapeutic use
  • Mass Spectrometry
  • Qualitative Research
  • SARS-CoV-2
  • South Africa / epidemiology
  • Tablets

Substances

  • Capsules
  • Tablets
  • Ivermectin