Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

Radiother Oncol. 2021 Jul:160:120-124. doi: 10.1016/j.radonc.2021.04.022. Epub 2021 May 6.

Abstract

This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.

Keywords: 4DCT scans; Dice Similarity; Functional avoidance; Lung cancer; SPECT ventilation/perfusion; Spearman correlation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Four-Dimensional Computed Tomography*
  • Humans
  • Lung / diagnostic imaging
  • Lung Neoplasms* / diagnostic imaging
  • Lung Neoplasms* / radiotherapy
  • Perfusion
  • Prospective Studies
  • Pulmonary Ventilation
  • Tomography, Emission-Computed, Single-Photon