Disseminated mucocutaneous herpes simplex virus (HSV) infection in nonpregnant and healthy women is a rare manifestation of primary genital inoculation. The literature contains relatively few cases of this type of infection in nonimmunocompromised adults. Furthermore, the majority of adult disseminated mucocutaneous infections have fulminant courses and terminate in death. In this report, a case of nonfatal disseminated mucocutaneous HSV type 2 infection is described in a nonimmunocompromised woman with a childhood history of immune thrombocytopenia purpura and splenectomy.